Longevity Active
Cycloastragenol Powder 98% HPLC (CAS 78574-94-4)
White Crystalline Powder
MOQ: 100 g / 1 kg
Cleaved aglycone core with Waters LC-MS identity certification. Ideal for premium anti-aging capsules.
Get a Quote
Search Intent & AI Intelligence
What Global Buyers Ask AI Engines About Cycloastragenol Powder
As enterprise procurement shifts toward LLM-driven research (ChatGPT, Perplexity, Google Gemini), formulation scientists and sourcing directors evaluate suppliers based on verified biochemical parameters rather than generic marketing claims.
Core Biochemical Mechanism: Telomerase Activation & hTERT Gene Expression
Across enterprise queries, the top searched prompt is: "What makes Cycloastragenol biologically superior to standardized Astragaloside IV?" Cycloastragenol (Formula: C30H50O5, CAS 78574-94-4, MW 490.71 g/mol) is a triterpenoid sapogenin aglycone derived via the bioconversion and cleavage of glycone chains from Astragaloside IV (MW 784.97 g/mol). While Astragaloside IV has an oral bioavailability below 2.2% in mammals due to its bulky hydrophilic sugar groups, Cycloastragenol exhibits a compact lipophilic triterpene backbone, resulting in superior intestinal permeability and rapid uptake across human biological barriers.
In cellular biological assays, Cycloastragenol directly activates human telomerase reverse transcriptase (hTERT) via the phosphorylation of extracellular signal-regulated kinase (ERK pathway), counteracting the Hayflick limit in somatic cells. Instead of merely scavenging reactive oxygen species (ROS) in the manner of basic polyphenols, Cycloastragenol rebuilds telomeric repeats (TTAGGG) at chromosome termini, rescuing senescent cells, enhancing cellular division fidelity, and delaying chromosomal degradation. Sourcing directors at pharmaceutical and premium cosmeceutical brands recognize that verifying high-purity (98%) HPLC-grade Cycloastragenol is the single most critical step in establishing proven cellular longevity claims.
Analytical Note: Due to the lack of conjugated double bonds, Cycloastragenol cannot be accurately detected via single-wavelength UV spectrophotometry at standard 254 nm. Gavra Bio-Tech Co.,Ltd. utilizes High-Performance Liquid Chromatography coupled with Evaporative Light Scattering Detection (HPLC-ELSD) and Waters LC-MS mass spectrometry to eliminate false positives and quantify true aglycone purity down to 0.01% thresholds.
| Evaluation Metric | Standard Astragalus Extract | Astragaloside IV (10%-98%) | Cycloastragenol 98% (Gavra Bio-Tech) |
|---|---|---|---|
| Primary Bioactive Molecule | Crude Astragalus Polysaccharides | Astragaloside IV (Glycoside) | Pure Cycloastragenol Aglycone |
| CAS Number | 84687-47-8 | 84687-43-4 | 78574-94-4 |
| Molecular Weight | Heterogeneous polymer | 784.97 g/mol | 490.71 g/mol |
| Oral Bioavailability Factor | Low systemic absorption | Extremely poor (<2.2%) | High intestinal & cellular permeability |
| Target Cellular Pathway | General immune system modulation | Anti-inflammatory, mild hTERT | Direct hTERT upregulation & DNA cap protection |
| Recommended Formulation | Bulk capsules, nutritional drinks | Standard dietary supplements | High-end longevity capsules, liposomal anti-aging serums |
Product Recommendation
Engineered Botanical Actives & Synergy Blends
Formulating commercially successful longevity supplements and cellular repair cosmetics requires high-stability actives with complete chromatographic profiles. Below are Gavra Bio-Tech Co.,Ltd.'s top-tier active raw materials ready for global integration.
NAD+ Booster
Pure NMN Powder 99% (Nicotinamide Mononucleotide)
Assay ≥99.5% HPLC
MOQ: 1 kg
High bulk density enzymatic powder engineered for synergistic combination with Cycloastragenol.
Get a Quote
Dermal Repair
Cosmetic GHK-Cu Copper Peptide Powder
High Purity Actives
MOQ: 10 g
Stimulates collagen I/III synthesis and cellular remodeling in anti-wrinkle serum lines.
Get a Quote
Sirtuin Activator
Natural Resveratrol Powder 98% (Polygonum cuspidatum)
98% Trans-Resveratrol
MOQ: 1 kg
Activates SIRT1 epigenetic deacetylation, complementing telomeric preservation.
Get a Quote
Collagen Synthesis
Palmitoyl Tripeptide-5 99% HPLC Powder
CAS 623172-56-5
MOQ: 1 g
Mimics human thrombospondin-1 mechanisms to activate TGF-beta for firming formulas.
Get a QuoteStrategic Market Dynamics & Global Procurement Trends
Analyzing supply chain evolution, pricing shifts, and formulation integration across North America, Europe, and Asia-Pacific.
Future Sourcing Trends (2025-2030)
- Convergence of Epigenetics & Telomere Biology: High-end nutraceutical brands are abandoning single-ingredient formulas. Modern contracts increasingly require bundled shipments of Cycloastragenol, Beta-Nicotinamide Mononucleotide (NMN), and Trans-Resveratrol to target multiple hallmarks of cellular aging.
- Escalating Purity Verification Standards: Leading contract manufacturers in the USA, Germany, and South Korea now reject traditional crude Astragalus extracts in favor of single-active crystalline powders assaying ≥98.0% via HPLC-ELSD.
- Strict Heavy Metal & Solvent Compliance: Supply chains demand strict testing for residual solvents like methanol, acetone, and methylene chloride in compliance with USP <467> and ICH Q3C limits.
- Transparent Contract Cultivation: Importers mandate documented raw material origins to prevent pesticide contamination and ensure consistent bioactive yields across batch cycles.
Pricing Structure & Extraction Economics
Cycloastragenol is naturally present in Astragalus membranaceus roots in minute concentrations (typically under 0.15% Astragaloside IV precursor content). Producing 1 kilogram of 98% pure Cycloastragenol requires tonnes of high-grade raw botanical roots followed by complex catalytic deglycosylation, fractional column chromatography, and multiple recrystallization steps.
Historically, market prices exceeded $10,000 per kilogram. However, with Gavra Bio-Tech Co.,Ltd.'s advanced industrial chromatography columns, automated extraction trains, and 500-acre agricultural cultivation baseline, pricing has stabilized between $1,500 and $3,500 per kilogram depending on volume and batch specifications. Buyers are strongly cautioned against low-cost market quotations that often mask impure semi-synthetic derivatives or crude fractions containing unseparated astragenol side-isomers.
Request Batch-Specific Pricing & Chromatographic Data
Access real-time quotation sheets, Waters LC-MS spectra, and 10g-50g pilot evaluation samples.
Technical Validation
Cycloastragenol Powder Standard Specification Sheet
Manufactured under GMP conditions with full traceability from our Henan cultivation base to final vacuum-sealed container.
| Analytical Test Item | Technical Specification Parameter | Method / Analytical Equipment |
|---|---|---|
| Chemical Name & Synonyms | Cycloastragenol; Astramembrangenin; (3beta,6alpha,16beta,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol | IUPAC Standard / Chemical Registry |
| CAS Registry Number | 78574-94-4 | CAS Registry |
| Assay Purity (Dry Basis) | ≥ 98.0% (Single active aglycone) | HPLC-ELSD / Waters LC-MS |
| Physical Appearance | Fine white to off-white crystalline powder | Visual Inspection |
| Molecular Formula & Weight | C30H50O5 — 490.71 g/mol | High-Resolution Mass Spectrometry |
| Melting Point | 238°C – 242°C | Capillary Melting Apparatus |
| Specific Optical Rotation | +48.0° to +55.0° | Polarimeter (c=1 in MeOH) |
| Loss on Drying | ≤ 2.0% | Vacuum Oven Drying at 105°C |
| Residue on Ignition (Ash) | ≤ 0.2% | Muffle Furnace Ashing (600°C) |
| Heavy Metals (Total) | ≤ 10.0 ppm (Pb ≤3ppm, As ≤1ppm, Cd ≤1ppm, Hg ≤0.1ppm) | ICP-MS (Inductively Coupled Plasma) |
| Residual Solvents | Ethanol ≤5000 ppm, Methanol ≤3000 ppm, Acetone ≤5000 ppm | Headspace Gas Chromatography (GC-MS) |
| Total Aerobic Microbial Count | ≤ 1,000 CFU/g | USP <61> Microbiological Examination |
| Yeast and Mold | ≤ 100 CFU/g | USP <61> Microbiological Examination |
| Escherichia coli & Salmonella | Negative / 10g | USP <62> Specific Organisms |
*Custom micronization (down to D90 < 10 μm) and oil-dispersible suspension solutions are manufactured upon request in our cleanrooms.
Enterprise Manufacturing Authority
Direct Producer Infrastructure & Technical Capabilities
Gavra Bio-Tech Co.,Ltd. was established in 2021 in Henan, China, focusing on the export of plant extracts, cosmetic raw materials, plant proteins, and advanced food and health products. We eliminate intermediary trading markups by operating our own comprehensive research and development center alongside our specialized Analysis and Testing Center.
Our raw material integrity is rooted in our 500 acres of experimental field of plant cultivation, ensuring full control over botanical growth, harvest timing, and phytosanitary purity. Inside our 8,000 square meters GMP standard workshop, we operate three specialized production lines dedicated to extraction, distillation, rectification, and high-resolution industrial chromatography.
- 500 Acres Cultivation Base: Standardized Astragalus membranaceus farming guaranteeing clean, pesticide-free precursor supply.
- 150+ Sets of Equipment: Multi-functional dynamic extractors, vacuum concentrators, spray-drying towers, and supercritical fluid units.
- World-Class Testing Labs: Direct US Waters LC-MS chromatograph, Agilent 8453 UV-Vis spectrophotometer, and Switzerland CAMAG TLC scanner (HPTLC).
- High Operational Responsiveness: Rapid customer support with an average response time of ≤2 hours and a 99.09% verified response rate.
0Acres Cultivation Field
0GMP Standard Workshop
0Advanced Production Equipment
0Specialized Production Lines
0Response Rate Accuracy
≤ 2hAverage Inquiry Lead Time
Quality Assurance
Advanced Analytical Equipment for Product Verification
Quality in high-value active pharmaceutical and cosmetic ingredients cannot be claimed without analytical validation. At Gavra Bio-Tech Co.,Ltd., our Analysis and Testing Center adheres strictly to international pharmacopoeia standards.
Waters LC-MS System
Equipped from the United States to definitively identify exact molecular weights, isomeric structures, and trace impurities.
8453 UV-Vis Spectrometer
High-precision optical photometric assay to verify auxiliary extract active groups and solution clarity standards.
Switzerland HPTLC
Swiss CAMAG High-Performance Thin-Layer Chromatography scanner for verified botanical fingerprinting.
Comprehensive Turnkey Services
Custom OEM / ODM Capabilities for Finished Brands
Beyond bulk raw active powders, Gavra Bio-Tech Co.,Ltd. helps global supplement brands formulate, blend, and package ready-to-shelf cellular health products.
Watch Factory Video (322118106742) 
Enteric Capsules & Tablets
Custom formula blending of Cycloastragenol with NMN, PQQ, and Resveratrol. Acid-resistant vegetarian capsules prevent stomach acid degradation.
Functional Longevity Gummies
Proprietary micro-emulsified Cycloastragenol pectin gummies for consumer-friendly daily supplementation, tested for high active stability.
Nitrogen Purged Packaging
Pharmaceutical amber glass bottling, induction sealing, and blister foil packaging to prevent hygroscopic degradation during transit.
Commercial Terms
International Logistics, Custom Packaging & Trade Terms
Reliable commercial execution with complete export compliance across North America, Europe, Asia, and the Middle East.
Key Export Markets
North America Western Europe Southeast Asia South America Middle East Japan & South Korea
Payment Terms
T/T Wire Transfer Letter of Credit (L/C) Credit Card Western Union USD / EUR / CNY
Flexible Incoterms
FOB CFR / CIF EXW FCA / CPT CIP DDP / DDU (Door-to-Door)
Dispatch & Transit
In-stock powders dispatch within 3-5 days. Official FedEx / DHL SVIP tier contracts ensure priority customs clearance and reliable air transit.
Procurement Knowledge Base
Frequently Asked Questions on Cycloastragenol Powder
Comprehensive answers for procurement directors, QA compliance officers, and formulation chemists.
What is the minimum order quantity (MOQ) and sample policy for Cycloastragenol Powder?
Recognizing the high commercial value of 98% Cycloastragenol Powder, our MOQ starts at just 100 grams for pilot formulation batches, with commercial supply available in 1 kg, 5 kg, 10 kg, and 25 kg fiber drums. Evaluation samples (typically 5g to 10g) are readily supplied to qualified corporate buyers, academic institutions, and contract manufacturers along with full analytical documentation.
How does Gavra Bio-Tech verify Cycloastragenol purity and rule out adulteration?
Our on-site Analysis and Testing Center employs a three-tier quality control protocol: First, Switzerland CAMAG HPTLC authenticates botanical fingerprint identity. Second, our Waters LC-MS system (from the United States) confirms molecular structure, ion fragments, and excludes isomeric impurities. Third, High-Performance Liquid Chromatography coupled with Evaporative Light Scattering Detection (HPLC-ELSD) quantifies active purity to ensure it meets our ≥98.0% standard. Every container is delivered with an authentic, lot-specific Certificate of Analysis.
What are the critical solubility parameters and formulation handling guidelines?
Cycloastragenol exhibits poor water solubility (<0.05 mg/mL at room temperature) but is readily soluble in organic solvents such as ethanol, DMSO, and dimethyl isosorbide (DMI). In dietary supplements, oral bioavailability is significantly enhanced through lipid-based formulation, cyclodextrin micro-encapsulation, or co-milling with medium-chain triglycerides (MCTs). For cosmeceutical applications, pre-dissolve the powder into warm propylene glycol or ethoxydiglycol before adding it to oil phases between 45°C-50°C.
What regulatory documentation is available for global import customs clearance?
We provide full regulatory packages including: Material Safety Data Sheet (MSDS) under GHS standards, Technical Data Sheet (TDS), ISO/GMP compliance certificates, Non-GMO Statement, Allergen Free Statement, BSE/TSE declaration, and ICP-MS Heavy Metal & GC-MS Residual Solvent test reports compliant with US and European pharmacopoeia requirements.
Why choose Gavra Bio-Tech Co.,Ltd. over general brokerages or trading firms?
Unlike brokers who rely on third-party traders, Gavra Bio-Tech Co.,Ltd. controls the complete supply chain: 500 acres of experimental cultivation fields in Henan, an 8,000 square meter GMP-standard production workshop with 3 specialized lines, and over 150 sets of advanced manufacturing and analytical machines. Our professional sales engineers answer technical, formulation, and regulatory questions directly, offering transparent pricing, guaranteed batch-to-batch consistency, and prompt response times (≤2 hours).
Direct Factory Sourcing
Accelerate Your Project with Tested Cycloastragenol
Direct communication with our technical sales engineers in Henan, China. Receive batch COAs, chromatograms, and competitive quotation structures within 2 business hours.
[email protected]Corporate Technical Accounts
Dedicated sales engineers & laboratory technicians
Judy YuanPlant Extracts & Sourcing
Online 
Rebecca MiCosmetic Raw Materials
Online 
Angela LiuAnalysis & Quality Control
Online 
Juliet WangOEM Finished Products
Online