Primary API
Tauroursodeoxycholic Acid (TUDCA) Powder 99%
CAS 14605-22-2
MOQ: 1 kg | In Stock
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B2B Advantages
≥99.0% HPLC Assay
8,000 m² GMP Standard
Waters LC-MS Tested
≤2h Response Guarantee
100% Synthetic / Cruelty-Free
Comprehensive Procurement Guide
What Global B2B Buyers Ask AI About Sourcing Tauroursodeoxycholic Acid (TUDCA) Powder: Purity, Synthesis, and Market Trends
A data-backed technical and commercial analysis for nutraceutical brand owners, procurement managers, compounding pharmacists, and regulatory compliance teams.
Understanding Tauroursodeoxycholic Acid (TUDCA): Mechanism, Structure & Grade Differentiation
Tauroursodeoxycholic Acid (TUDCA, CAS No. 14605-22-2, Molecular Formula: C26H45NO6S, Molecular Weight: 499.70 g/mol) is the taurine-conjugated hydrophilic derivative of ursodeoxycholic acid (UDCA). In biological systems, endogenous bile acids exist along a hydrophilicity-hydrophobicity continuum. While highly hydrophobic bile acids such as lithocholic acid (LCA) and deoxycholic acid (DCA) exert cellular detergent toxicity, induce mitochondrial membrane permeability transition, and stimulate reactive oxygen species (ROS), TUDCA operates as an endogenous molecular chaperone and cell-survival signaling molecule.
Specifically, TUDCA protects cells against Endoplasmic Reticulum (ER) stress by attenuating the unfolded protein response (UPR). When protein folding capacity is exceeded, sensor kinases such as PERK, IRE1α, and ATF6 trigger apoptotic cascades via downstream caspase-12 and CHOP expression. Exogenous supplementation with pharmaceutical-grade TUDCA powder stabilizes protein conformation, prevents toxic aggregate accumulation, and blocks pro-apoptotic Bax translocation to the outer mitochondrial membrane. Because of these distinct cytoprotective, cytolytic-inhibiting, and choleretic properties, commercial demand for pure, high-potency TUDCA powder has expanded far beyond traditional liver disease therapies into sports recovery formulations, metabolic longevity compounds, cognitive neuroprotection, and ophthalmic formulations.
Synthetic Precision vs. Animal Bile Derivatives: Resolving Sourcing Ambiguities
Historically, bile acids were extracted from mammalian gallbladders, most notably in traditional pharmacopeias utilizing bear bile (seleno-ursus thibetanus). Modern international procurement has transitioned away from natural extraction due to three critical factors: rigorous animal welfare legislation (CITES enforcement), severe batch-to-batch variability, and the grave danger of cross-contamination with zoonotic pathogens, heavy metals, and variable cholic/chenodeoxycholic acid ratios.
Gavra Bio-Tech Co.,Ltd. utilizes an advanced synthetic pathway: high-purity Ursodeoxycholic Acid is conjugated with synthetic taurine in an eco-optimized peptide-bond reaction under controlled stoichiometry. The crude conjugate undergoes multi-stage fractional crystallization, specialized chromatography, and precision vacuum lyophilization. The resulting crystalline powder is 100% free of animal DNA, vegan-compliant, halogen-free, and yields an ultra-pure assay exceeding 99.0% validated by High-Performance Liquid Chromatography (RP-HPLC).
Bile Acid Comparative Matrix for Formulators
Technical evaluation of hydrophobic index, solubility, and physiological applications.
| Compound Name | CAS Number | Hydrophobic Index | Aqueous Solubility (25°C) | ER Stress Chaperone Action | Primary Industrial Application |
|---|---|---|---|---|---|
| Tauroursodeoxycholic Acid (TUDCA) | 14605-22-2 | -0.47 (Highly Hydrophilic) | >50 mg/mL (Freely Soluble) | Potent Chaperone / UPR Suppressor | Dietary Supplements, Longevity, Hepatoprotection |
| Ursodeoxycholic Acid (UDCA) | 128-13-2 | +0.42 (Moderately Hydrophobic) | <0.05 mg/mL (Poorly Soluble) | Weak Direct Action | Prescription Gallstone Dissolution |
| Chenodeoxycholic Acid (CDCA) | 474-25-9 | +0.98 (Hydrophobic) | Slightly Soluble | None (Cytotoxic at High Doses) | FXR Receptor Agonist Research |
| Cholic Acid (CA) | 81-25-4 | +0.55 (Intermediate) | Sparingly Soluble | None | Emulsifier Synthesis, Chemical Intermediate |
Recommended TUDCA Formats & Complementary Actives
Standardized raw materials manufactured for nutraceutical encapsulation, blending, and compounding.
Industry Intelligence & Analytics
Future Procurement & Development Trends for TUDCA Powder (2025–2030)
Market vectors, regulatory trajectories, and formulation patterns steering global supply chain strategies.
1. Explosive Growth in Metabolic Longevity & Anti-Aging Stacks
While formerly confined to niche liver-support bodybuilding formulas, TUDCA is now widely recognized as a foundational cellular proteostasis agent. Global clinical interest in endoplasmic reticulum proteotoxicity has catalyzed major longevity brands to integrate TUDCA with NAD+ precursors (NMN, NR), Ca-AKG, and spermidine. Sourcing forecasts indicate a CAGR exceeding 14.8% through 2030 for high-purity crystalline TUDCA powder in North American and European premium longevity markets.
2. Regulatory Tightening on Residual Impurities & Heavy Metals
With international regulatory bodies (US FDA cGMP 21 CFR 111, EFSA, and TGA) increasing scrutiny over synthetic residual intermediates, bulk buyers can no longer rely on unverified non-specific titration tests. Sourcing demands have shifted towards chromatographically characterized batches specifying individual related impurities (<0.1%), zero chlorohydrin or ethylene oxide residue, and ICP-MS heavy metal limits meeting California Proposition 65 requirements.
3. Upstream Scale Consolidation & Direct Factory Contracting
Fluctuations in cholic acid precursor feedstocks have previously led to volatile spot pricing. Brand procurement strategies are aggressively transitioning from multi-tiered intermediate brokers to direct contracts with scalable Chinese production platforms. Companies equipped with dedicated R&D centers, on-site chromatography suites, and large-scale synthesis capacities provide indispensable buffer stock, predictable volume price tiers, and complete documentation security.
Analytical Standard
Technical Specification Certificate of Tauroursodeoxycholic Acid
Manufacturer analytical release parameters. Every lot is verified by LC-MS and UV-Vis spectrophotometry.
| Test Parameter | Compendial Standard | Typical Batch Result | Methodology & Instrumentation |
|---|---|---|---|
| Chemical Name | 2-[[(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid | Conforms to Structure | 1H-NMR / Waters LC-MS Identification |
| CAS Number | 14605-22-2 | Verified | Chemical Inventory Cross-Check |
| Appearance | White or off-white crystalline fine powder | Conforms (Pure White) | Visual / Organoleptic Inspection |
| Assay (Purity on Dry Basis) | ≥ 99.0% | 99.42% | RP-HPLC (C18 Column, UV 210nm) |
| Specific Optical Rotation | +40.0° to +46.0° | +43.2° | Automatic Polarimeter @ 20°C |
| Related Substances (Individual) | ≤ 0.5% (Any single impurity) | < 0.18% | HPLC Peak Area Normalization |
| Loss on Drying | ≤ 1.5% | 0.74% | Thermogravimetric Gravimetry (105°C, 3h) |
| Residue on Ignition (Sulfated Ash) | ≤ 0.2% | 0.08% | Muffle Furnace Ashing (600°C) |
| Heavy Metals (as Pb) | ≤ 10 ppm | < 2 ppm | ICP-MS Inductively Coupled Plasma |
| Arsenic (As) / Lead (Pb) / Cadmium (Cd) | As ≤ 1.0 ppm | Pb ≤ 1.0 ppm | Cd ≤ 0.5 ppm | Undetected / Within Limits | ICP-MS Quantitative Analysis |
| Total Aerobic Microbial Count (TAMC) | ≤ 1,000 CFU/g | < 100 CFU/g | USP <61> Microbiological Examination |
| Yeast & Mold Count (TYMC) | ≤ 100 CFU/g | < 20 CFU/g | USP <61> Microbiological Examination |
| Escherichia coli / Salmonella | Negative / Absent in 10g | Absent | USP <62> Specified Microorganisms |
Detailed batch Certificate of Analysis (COA), LC-MS spectra, and 3rd party accredited lab reports (Eurofins / SGS) are available upon request.
Enterprise Reliability & Manufacturing Power
Direct From the Source: Gavra Bio-Tech Co.,Ltd.
Established in 2021 in Henan, China, Gavra Bio-Tech Co.,Ltd. is a high-technology enterprise specializing in the research, chemical synthesis, extraction, and global export of bioactive ingredients, pharmaceutical intermediates, plant extracts, cosmetic raw materials, and plant proteins.
Operating with a comprehensive annual revenue between US$2.5 Million and US$5 Million and serving business partners across North America, Europe, Southeast Asia, and the Middle East, we maintain an outstanding industry-leading response rate of 99.09% with an average initial technical response within 2 hours. Our customer loyalty is demonstrated by our 19% repeat reorder rate among tier-1 formulation laboratories.
- 8,000 m² GMP-Standard Workshop: State-of-the-art cleanroom production adhering to strict ISO and GMP hygiene protocols.
- 150+ Sets of Processing & Analytical Units: Comprehensive synthesis, extraction, distillation, rectification, and preparative chromatography lines.
- 500 Acres Experimental Base: Dedicated cultivation and botanical validation testing grounds safeguarding raw supply chains.
- World-Class Analytical Testing Center: In-house quality verification powered by US-imported Waters LC-MS chromatographs, 8453 UV-Vis spectrophotometers, and Switzerland CAMAG HPTLC scanners.
- Engineering-Led Sales Support: Direct communication with technical chemical engineers ready to assist with dissolution profiles, stability data, and custom milling.
0GMP-Standard Workshop
0Sets Advanced Equipment
0Verified Response Rate
≤2hAverage Response Time
0Acres Cultivation Field
0HPLC Product Assay
Zero Quality Compromise
Advanced Instrumentation & In-House Analysis Center
Every batch of Tauroursodeoxycholic Acid TUDCA powder undergoes exhaustive structural validation, chemical assay calculation, and residual solvent screening before release.
Waters LC-MS
US Waters Liquid Chromatography-Mass Spectrometry confirming precise molecular weight (499.70) and trace impurity identification.
8453 UV-Vis
High-precision spectrophotometric absorbance analysis and photometric quantitation against primary pharmacopeial standards.
Switzerland HPTLC
Automated High-Performance Thin-Layer Chromatography scanner ensuring qualitative fingerprinting and chemical purity verification.
End-to-End Formulation Services
Turnkey OEM & Contract Manufacturing Solutions
From pure bulk active ingredients to finished, shelf-ready retail dietary supplements.
Watch Factory Tour
OEM Hard Capsules & Tablets
Custom filled vegetarian (HPMC) or gelatin capsules containing 250mg, 500mg, or customized combination synergistic blends (TUDCA + NAC + Milk Thistle).
Private Label Bottling & Pouches
Turnkey packaging options from 100g sample containers to HDPE pharmaceutical induction-sealed bottles and child-proof heat-sealed aluminum pouches.
Global Direct-to-Door Logistics
Fast customs clearance with SVIP courier dispatch via FedEx and DHL. Full DDP (Delivered Duty Paid) shipping to the USA, Canada, UK, and EU.
Commercial Procurement
Global B2B Logistics, Payment Terms & Compliance
Flexible supply agreements structured to streamline international supply chains.
Key Export Destinations
United StatesCanadaGermanyUnited KingdomAustraliaJapanBrazilUAE
Accepted Payments
T/T WireL/C at SightCredit CardWestern UnionUSD / EUR / CNY
Incoterms Supported
FOB Shanghai/QingdaoCFRCIFEXWDDP (Duty Paid)CIPExpress Door-to-Door
Turnaround & Lead Time
Inventory ready for dispatch within 3-5 business days. Custom synthesis, large-scale lots (>500 kg), and private-label OEM delivered within 12–18 days.
Frequently Asked Questions
Tauroursodeoxycholic Acid (TUDCA) Powder Procurement FAQ
In-depth technical and regulatory answers for chemical procurement specialists.
What is the exact assay specification and analytical method for Gavra's TUDCA powder?
Our Tauroursodeoxycholic Acid (TUDCA) bulk powder is manufactured to guarantee a minimum assay of ≥ 99.0% on a dried basis. Every batch is analyzed via reversed-phase High-Performance Liquid Chromatography (RP-HPLC) utilizing an octadecylsilyl (C18) silica column, UV detection at 210 nm, and a calibrated mobile phase buffer system. Mass confirmation is performed using our Waters LC-MS system to ensure absolute freedom from UDCA precursor residue, taurine fragments, or diastereomeric impurities.
Is this TUDCA powder synthetic or extracted from animal bear/bovine bile?
Gavra Bio-Tech Co.,Ltd. exclusively supplies 100% synthetically conjugated TUDCA powder. We do not extract from bear, porcine, or bovine bile. Our compound is produced via precision chemical conjugation of pharmaceutical-grade ursodeoxycholic acid with high-grade synthetic taurine. This eliminates ethical concerns, eliminates endangered species CITES restrictions, prevents animal viral cross-contamination, and delivers superior chemical consistency compared to biological extracts.
How does TUDCA powder compare chemically and commercially to UDCA?
UDCA (Ursodeoxycholic Acid) is poorly water-soluble and relies heavily on natural hepatic conjugation before becoming systematically bioavailable. TUDCA is pre-conjugated with taurine, rendering it completely hydrophilic and highly water-soluble (>50 mg/mL). Chemically, TUDCA acts directly as a chemical chaperone crossing the blood-brain barrier to alleviate endoplasmic reticulum (ER) stress. In the commercial supplement marketplace, TUDCA commands higher consumer recognition and margins in sports performance, nootropic, and cellular longevity formulations.
What regulatory and quality documentation is supplied with wholesale orders?
We provide a complete regulatory packet with each shipment, including:
- Lot-specific Certificate of Analysis (COA) containing assay and physical properties
- Actual HPLC & LC-MS Chromatographic Reports
- Heavy Metal Trace Analysis via ICP-MS (Pb, Cd, As, Hg)
- Residual Solvents GC Report conforming to USP <467> / ICH Q3C
- Material Safety Data Sheet (MSDS / SDS conforming to GHS)
- TSE/BSE-Free Statement, Non-GMO Certification, and Allergen Declarations
What are the storage recommendations and re-test shelf life for TUDCA powder?
Tauroursodeoxycholic Acid is slightly hygroscopic due to its hydrophilic taurine moiety. It must be stored in airtight containers, shielded from direct sunlight, excessive heat, and moisture. When maintained in original unopened packaging below 25°C with relative humidity <60%, the compound exhibits extraordinary chemical stability with a validated re-test period of 24 to 36 months.
What is your Minimum Order Quantity (MOQ) and packaging standard?
Our standard Minimum Order Quantity (MOQ) for Tauroursodeoxycholic Acid powder is 1 kg, hermetically packed in double food-grade polyethylene interior bags enclosed in heat-sealed multi-layer aluminum foil barrier pouches. For commercial industrial lots, standard packing consists of 25 kg fiber drums lined with dual polyethylene liners, desiccants, and tamper-evident outer seals.
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Request Bulk Pricing & Analytical COA for TUDCA Powder
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[email protected]Technical Sourcing Engineers
Average response time ≤ 2 hours (99.09% response rate)
Judy YuanTUDCA & Active Ingredients
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Rebecca MiCosmetics & API Compliance
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Juliet WangOEM Capsules & Contract Blending
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